A two-phase strategy for treatment of oxidant-dependent cancers.

In many cancers, a chronic increase in oxidant stress - associated with elevated levels of hydrogen peroxide - contributes to the increased proliferative rate, diminished apoptosis, increased angiogenic and metastatic capacity, and chemoresistance that often characterize advanced malignancies. Read More >>

PPARgamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation.

McCarty MF, Barroso-Aranda J, Contreras F. (June 2nd, 2007)

The ability of metronomic chemotherapy to induce endothelial apoptosis has been traced to increased endothelial expression of thrombospondin-1, which activates endothelial CD36 receptors, triggering the extrinsic apoptotic pathway. Read More >>